Zwitterionic capsular polysaccharides: the new MHCII-dependent antigens
- 8 August 2005
- journal article
- review article
- Published by Hindawi Limited in Cellular Microbiology
- Vol. 7 (10) , 1398-1403
- https://doi.org/10.1111/j.1462-5822.2005.00591.x
Abstract
The immune system has evolved the ability for T cells to recognize nearly any biological polymer, including peptides, protein superantigens, and glycolipids through presentation by the major histocompatibility complex (MHC) proteins such as MHC class I (MHCI), MHC class II (MHCII), and CD1. A recent and unexpected addition to this list is the zwitterionic capsular polysaccharide (ZPS). These bacterial molecules utilize MHCII presentation to activate T cells via recognition by alphabeta T cell receptor (alphabetaTCR) proteins. In this review, we explore what is currently known about ZPS processing and presentation within antigen-presenting cells (APCs) and the immune response that follows.Keywords
This publication has 27 references indexed in Scilit:
- An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune SystemCell, 2005
- Effect of B7-2 and CD40 Signals from Activated Antigen-Presenting Cells on the Ability of Zwitterionic Polysaccharides To Induce T-Cell StimulationInfection and Immunity, 2005
- CD1: Antigen Presentation and T Cell FunctionAnnual Review of Immunology, 2004
- Redox signaling in macrophagesMolecular Aspects of Medicine, 2001
- CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULESAnnual Review of Immunology, 1997
- Structural Features of Polysaccharides That Induce Intra-Abdominal AbscessesScience, 1993
- Use of a Model of Intraabdominal Sepsis for Studies of the Pathogenicity of Bacteroides fragilisClinical Infectious Diseases, 1984
- Structure of native polysaccharide antigens of type Ia and type Ib group B StreptococcusBiochemistry, 1983
- Surface Antigens as Virulence Factors in Infection with Bacteroides fragilisClinical Infectious Diseases, 1979
- Isolation and Identification of Encapsulated Strains of Bacteroides fragilisThe Journal of Infectious Diseases, 1977