Dominant negative myostatin produces hypertrophy without hyperplasia in muscle
Open Access
- 23 May 2000
- journal article
- Published by Wiley in FEBS Letters
- Vol. 474 (1) , 71-75
- https://doi.org/10.1016/s0014-5793(00)01570-2
Abstract
Myostatin, a TGF‐β family member, is a negative regulator of muscle growth. Here, we generated transgenic mice that expressed myostatin mutated at its cleavage site under the control of a muscle specific promoter creating a dominant negative myostatin. These mice exhibited a significant (20–35%) increase in muscle mass that resulted from myofiber hypertrophy and not from myofiber hyperplasia. We also evaluated the role of myostatin in muscle degenerative states, such as muscular dystrophy, and found significant downregulation of myostatin. Thus, further inhibition of myostatin may permit increased muscle growth in muscle degenerative disorders.Keywords
This publication has 30 references indexed in Scilit:
- Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart.Journal of Clinical Investigation, 1998
- A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattleNature Genetics, 1997
- Latent transforming growth factor-β: Structural features and mechanisms of activationKidney International, 1997
- Regulation of skeletal muscle mass in mice by a new TGF-p superfamily memberNature, 1997
- Mutations that disrupt the carboxyl-terminus of gamma-sarcoglycan cause muscular dystrophyHuman Molecular Genetics, 1996
- Defining the regulatory networks for muscle developmentCurrent Opinion in Genetics & Development, 1996
- Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.Genes & Development, 1995
- Localization of dystrophin to postsynaptic regions of central nervous system cortical neuronsNature, 1990
- THE mdx MOUSE SKELETAL MUSCLE MYOPATHY: II. CONTRACTILE PROPERTIESNeuropathology and Applied Neurobiology, 1988
- Electron microscopic and autoradiographic characterization of hindlimb muscle regeneration in the mdx mouseThe Anatomical Record, 1987