GASTRIC CARCINOMA IN DOGS PRODUCED BY THE COMBINED USE OF N‐ETHYL‐N'‐NITRO‐N‐NITROSOGUANIDINE (ENNG) AND GASTRIN

Abstract
Eight 4 mo. old beagle dogs, received both oral administration of N-ethyl-N''-nitro-N-nitrosoguanidine (ENNG) and s.c. injection of gastrin. One of them had an annularly infiltrating advanced carcinoma with marked fibrous thickening of the antral wall resulting in stenosis of the antrum (carcinoma scirrhosum) which resembled Linitis plastica (Borrmann''s type IV carcinoma) in the human stomach.