INVIVO KINETICS OF BLOOD CHOLINESTERASE INHIBITION BY "9-AMINO-1,2,3,4-TETRAHYDROACRIDINE, ITS 7-METHOXY DERIVATIVE AND PHYSOSTIGMINE IN RATS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 28  (1) , 31-34
Abstract
In vivo inhibition of blood acetylcholinesterase [AChE, EC 3.1.1.7] activity after intoxication by 9-amino-1,2,3,4-tetrahydroacridine [tacrine] its 7-methoxy derivative [MTX] and physostigmine was studied in rats. Changes of enzyme activity in the blood were continually registered using an automatic colorimeter Auto Analyzer system. The dependence of percent enzyme inhibition on time in semilogarithmic transformation was characterized by a 2 phase curve. The 1st phase reflected the increase in the concentration of inhibitors in the blood during their resorption, followed by a slow 2nd phase of inhibition. The inhibitory effect decreased in the order physostigmine > tacrine > MTX. The relationship between the anticholinesterase and antipsychotomimetic action of the substances is discussed.

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