IODINE EXCRETION IN URINE, SALIVA, GASTRIC JUICE AND SWEAT IN DEHALOGENASE DEFICIENCY

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Abstract
SUMMARY: The excretion of iodine in urine, saliva, gastric juice and sweat has been studied by using 131I-labelled monoiodotyrosine in a patient with the dehalogenase type of dyshormonogenesis. Iodinated components 'x', iodide, monoiodotyrosine and 'y' were found in the urine. A previously undescribed component (compound 'u') accounted for a large fraction of the urinary radioactive iodine. Organic iodinated compounds were not excreted in the saliva. Only inorganic iodide was found in the gastric juice. No organic iodine was detected in the sweat. The plasma inorganic iodine (PII) derived from salivary iodine measurements gave low values indicative of iodine deficiency. The PII values obtained from the urinary iodine were falsely high due to the presence of organic iodinated compounds.