Marked Healing-Promoting Action of Cimetidine on Acetic Acid-Induced Ulcer in Rats with a Limited Food-Intaking-Time

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Abstract
The effect of cimetidine on ulcer healing was investigated in rats with acetic acid induced ulcer who were permitted to intake food only between 9:30-10:30 a.m. and 6:00-7:00 p.m. When evaluated on the 15th and 21st days after operation, cimetidine (100 mg/kg .times. 2 day, p.o.) markedly decreased the ulcer index and the defective area of the ulcerated region. Moreover, this agent pronouncedly increased the decreasing index of exposed ulcer floor and the mucosal regeneration index. On the 21st day, the thickness of the ulcer base was decreased by this agent, the involution of granulation being indicated. Thus, marked healing-promoting action of cimetidine on acetic acid-induced ulcer was observed by limiting the food-intaking-time.