Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABAA receptors
- 28 February 1999
- journal article
- Published by Elsevier in Neuropharmacology
- Vol. 38 (2) , 267-271
- https://doi.org/10.1016/s0028-3908(98)00172-5
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- Neurosteroid Analogues. 6. The Synthesis and GABAA Receptor Pharmacology of Enantiomers of Dehydroepiandrosterone Sulfate, Pregnenolone Sulfate, and (3α,5β)-3-Hydroxypregnan-20-one SulfateJournal of Medicinal Chemistry, 1998
- Neurosteroid analogues. Part 5.1 Enantiomers of neuroactive steroids and benz[e]indenes: total synthesis, electrophysiological effects on GABAA receptor function and anesthetic actions in tadpolesJournal of the Chemical Society, Perkin Transactions 1, 1997
- Desensitization and noncompetitive blockade of GABAA receptors in ventral midbrain neurons by a neurosteroid dehydroepiandrosterone sulfateSynapse, 1994
- Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptorEuropean Journal of Pharmacology: Molecular Pharmacology, 1990
- The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptorBrain Research, 1990
- Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequencyBrain Research, 1989
- Complex interactions between pregnenolone sulfate and the t-butylbicyclophosphorothionate-labeled chloride ionophore in rat brainBrain Research, 1989
- Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neuronsNeuroscience Letters, 1988
- Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in brain?Brain Research, 1987
- Structure-activity relationships in steroidal anaestheticsJournal of Steroid Biochemistry, 1975