Slow Tremor and Delayed Brainstem Auditory Evoked Responses in Alcoholics

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Abstract
• Interpeak intervals of the auditory brainstem evoked electric response (ABR) were measured in 13 patients showing a characteristic slow rhythmic tremor and a more or less marked chronic cerebellar ataxia. Eleven of these patients were advanced alcoholics; two were less severe alcoholics. The tremor appeared primarily in the legs, and displayed distinctive features when examined in appropriate postures. Ten of the patients displayed a significant increase of the I-V interval of the ABR. The occurrence of the slow tremor with abnormal electric brainstem responses may provide objective evidence of lesions affecting extracerebellar regions of the CNS.