Idiopathic recurring stupor: A case with possible involvement of the gamma–aminobutyric acid (GABA)ergic system
- 1 May 1992
- journal article
- case report
- Published by Wiley in Annals of Neurology
- Vol. 31 (5) , 503-506
- https://doi.org/10.1002/ana.410310507
Abstract
A patient had recurrent spontaneous episodes of stupor or coma in the absence of toxic, metabolic, or structural brain damage. Ictal electroencephalography showed fast 14 Hz background activity; sleep studies excluded narcolepsy. Flumazenil (Anexate), a benzodiazepine antagonist, promptly resolved the episodes and normalized the electroencephalogram. Radioreceptor binding studies showed the presence of a ligand to the central benzodiazepine receptor in plasma and cerebrospinal fluid during the episodes, suggesting a gamma‐aminobutyric acid (GABA)ergic system involvement in the origin of the attacks.Keywords
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