MULTIPLE ANTIBIOTIC-RESISTANCE IN ACTINOMYCETES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 13  (10) , 1831-1842
Abstract
Native strains of actinomycetes from 3 groups of Streptomyces (blue, gray and globisporin) were characterized for their resistance to antibiotics and sulfamides. Most strains possessed stably inheritable multiple resistance to many antibiotics. The resistance of a number of strains to the aminoglycoside antibiotics and penicillins appears to be due to the presence of inactivating enzymes in these strains. The resistance to erythromycin, lincomycin, tetracycline and ristomycin is probably of inducible nature in S. coelicolor A3(2). Linkage analysis for resistance determinants in pairs suggests random distribution of the majority of determinants among tested strains. Non-random distribution was shown for determinants of resistance to tetracycline, chloramphenicol and ristomycin in Tc Cm, Tc Rm, Cm Rm combinations.