Interleukin-15-Deficient Mice Develop Protective Immunity toToxoplasma gondii

Open Access

1 November 2004

journal article
Published by American Society for Microbiology in Infection and Immunity

Vol. 72 (11) , 6729-6732
https://doi.org/10.1128/iai.72.11.6729-6732.2004

Abstract

Previous studies have suggested an important role for interleukin-15 (IL-15) in resistance to and memory forToxoplasma gondiiinfection. The studies presented here reveal that IL-15 is not required for infection-induced expansion of NK or CD8⁺T cells. Furthermore, IL-15^−/−mice develop long-term protective immunity to this pathogen.

Keywords

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