Action of Human Gastric Juice on Human Blood Clots

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Abstract
Incubation of normal human blood clots with normal human gastric juice leads to a lysis of the clot, most of which occurs in the first 15 min. of incubation. There is an inverse relationship between clot lysis and the pH of the gastric juice. At pH greater than 6, clots gain wt. Dilution with 0.1N HCl intensifies the lysis up to 60% concn. of the juice. At lesser concns. lysis diminishes until eventually the clot gains wt. rather than lyses. Clots gain wt. when exposed to boiled gastric juice. The greater the cell content of the clot, the more it appeared to resist lysis. Clots derived from plasma alone were completely lysed within a few minutes. The clot lytic activity of normal human gastric juice seems to be a function of the concn. and pH of the juice and the cellular content of the clot. Where peptic activity is greatly reduced or absent, swelling and not lysis of the clot occurs. Moderate dilution enhances the clot lytic activity of juice as it does the rate of coagulation of normal blood and plasma.