Stability of Antibiotics Used for Antibiotic-Lock Treatment of Infections of Implantable Venous Devices (Ports)
- 1 August 1999
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 43 (8) , 2074-2076
- https://doi.org/10.1128/aac.43.8.2074
Abstract
Antibiotic-lock is a treatment for catheter-related bloodstream infections in which a solution containing heparin and an antibiotic dwells in the lumen of the catheter or port. We tested the stability of vancomycin, cefazolin, ticarcillin-clavulanic acid, ceftazidime, or ciprofloxacin combined with heparin after incubation in vitro at 25 or 37°C for intervals of up to 10 days by bioassay. All the antibiotic solutions except ceftazidime retained ≥90% activity at both 25 and 37°C. Thus, studies of antibiotic-heparin lock solutions with dwell times of up to 10 days are feasible.Keywords
This publication has 15 references indexed in Scilit:
- Cure of Implantable Venous Port–Associated Bloodstream Infections in Pediatric Hematology‐Oncology Patients without Catheter RemovalClinical Infectious Diseases, 1999
- Intraluminal Antibiotic Treatment of Central Venous Catheter Infections in Patients Receiving Parenteral Nutrition at HomeClinical Infectious Diseases, 1995
- Treatment of Hickman Catheter Sepsis Using Antibiotic Lock TechniqueInfection Control & Hospital Epidemiology, 1995
- PRELIMINARY RESULTS TREATING PERSISTENT CENTRAL VENOUS CATHETER INFECTIONS WITH THE ANTIBIOTIC LOCK TECHNIQUE IN PEDIATRIC PATIENTSThe Pediatric Infectious Disease Journal, 1994
- A new approach to the management of Broviac catheter infectionJournal of Hospital Infection, 1992
- Complications of Indwelling Venous Access Lines in the Pediatric Hematology PatientJournal of Pediatric Hematology/Oncology, 1991
- Conventional and Nonconventional Modes of Vancomycin Administration to Decontaminate the Internal Surface of Catheters Colonized with Coagulase‐Negative StaphylococciJournal of Parenteral and Enteral Nutrition, 1990
- Antibiotic-lock technique is an effective treatment of bacterial catheter-related sepsis during parenteral nutritionClinical Nutrition, 1990
- Antibiotic‐Lock Technique: A New Approach to Optimal Therapy for Catheter‐Related Sepsis in Home‐Parenteral Nutrition PatientsJournal of Parenteral and Enteral Nutrition, 1988
- A Dilute Solution of Vancomycin and Heparin Retains Antibacterial and Anticoagulant ActivitiesThe Journal of Infectious Diseases, 1988