OCULAR ANTI-INFLAMMATORY ACTION OF IMIDAZOLE
- 1 January 1977
- journal article
- research article
- Vol. 16 (1) , 66-69
Abstract
Imidazole administered i.p. albino rabbits at a dose of 250 mg/kg inhibited the rise of aqueous humor protein conentration by approximately 50% 30 min after paracentesis. Systemic imidazole administered daily to albino rabbits injected with intravitreal Shigella endotoxin decreased the conjunctival and iris hyperemia and reduced the anterior chamber cell and flare and the haziness of the optical media. Systemically administered imidazole had no effect on the aqueous humor concentrations of c[cyclic]AMP or cGMP in the rabbit. In vitro studies of rabbit ciliary body-iris phosphodiesterase activity indicated no effect of imidazole at a concentration of 10-3 M.This publication has 3 references indexed in Scilit:
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