The intramitochondrial ATP/ADP‐ratio controls cytochrome c oxidase activity allosterically1
Open Access
- 29 January 1999
- journal article
- Published by Wiley in FEBS Letters
- Vol. 443 (2) , 105-108
- https://doi.org/10.1016/s0014-5793(98)01694-9
Abstract
Recently the signal transduction function for oxidative phosphorylation was found to be second order in ADP [Jeneson, J.A.L., Wiseman, R.W., Westerhoff, H.V. and Kushmerick, M.J. (1996) J. Biol. Chem. 271, 27995–27998], but the molecular mechanism of signal transduction remained unclear. Previously we described inhibition of cytochrome c oxidase by intramitochondrial ATP, accompanied by a change of hyperbolic into sigmoidal kinetics. The present study describes a sigmoidal relationship also between the ascorbate respiration of reconstituted cytochrome c oxidase and intraliposomal ADP concentration. Its possible role in the control of oxidative phosphorylation and cell respiration is discussed.Keywords
This publication has 23 references indexed in Scilit:
- In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cellsProceedings of the National Academy of Sciences, 1997
- The Signal Transduction Function for Oxidative Phosphorylation Is at Least Second Order in ADPJournal of Biological Chemistry, 1996
- The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 ÅScience, 1996
- Control of oxidative phosphorylation in rat muscle mitochondria: implications for mitochondrial myopathiesBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1993
- Regulation of the oxidative phosphorylation rate in the intact cellBiochemistry, 1990
- Multiple controls of oxidative metabolism in living tissues as studied by phosphorus magnetic resonance.Proceedings of the National Academy of Sciences, 1986
- Measurement of an individual rate constant in the presence of multiple exchanges: application to myocardial creatine kinase reactionBiochemistry, 1986
- [4] Isozymes of cytochrome-c oxidase: Characterization and isolation from different tissuesPublished by Elsevier ,1986
- Control of mitochondrial respirationFEBS Letters, 1983
- Keilin's Respiratory Chain Concept and Its Chemiosmotic ConsequencesScience, 1979