Clinicopathological Features of and Risk Factors for Multiple Primary Melanomas
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Open Access
- 5 October 2005
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 294 (13) , 1647-1654
- https://doi.org/10.1001/jama.294.13.1647
Abstract
The phenomenon of multiple primary tumors occurring within a single organ or organ system has been well documented.1 Whether this is a function of an increased genetic susceptibility of the individual patient (eg, in familial polyposis and colorectal cancer), consistent exposure to a common exogenous promoter of malignancy (eg, cigarette smoke and lung cancer), or a combination of these 2 factors varies from one patient to the next and from one organ system to the next. Malignant melanoma epitomizes much of what is known about multiple primary tumors.Keywords
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