Focal acantholytic dyskeratosis in experimental oral carcinogenesis in rats
- 1 January 1983
- journal article
- research article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 12 (1) , 30-36
- https://doi.org/10.1111/j.1600-0714.1983.tb00313.x
Abstract
Thrice weekly applications of carcinogen 4‐nitroquinoline N‐oxide to rat oral mucosa, induced focal acantholytic dyskeratosis (FAD) in about 50% of the animals. Mucosa overlying bone (palate and attached buccal gingiva) was the area of predilection. The number of oral foci per affected animal ranged between 1 and 3. Histologically, the experimental FAD foci showed all the characteristic features described for human focal acantholytic dyskeratosis. FAD appeared unrelated to malignancy development. It is suggested that FAD represents an induced epithelial differentiation or maturation defect caused by a variety of stimuli among which are chemical carcinogens. The present experimental model seems suitable for further histo‐ and cytopathogenetic studies.This publication has 21 references indexed in Scilit:
- Carcinogenesis in forestomach and changes in oral mucosa of rats induced by intragastric N‐methylnitrosoureaEuropean Journal of Oral Sciences, 1982
- Warty dyskeratoma of oral mucosaOral Surgery, Oral Medicine, Oral Pathology, 1981
- Oral focal acantholytic dyskeratosisOral Surgery, Oral Medicine, Oral Pathology, 1981
- Oral warty dyskeratomaArchives of Dermatology, 1980
- Effects of the water-soluble carcinogen 4-nitroquinoline N-oxide on hamster lingual mucosaOral Surgery, Oral Medicine, Oral Pathology, 1977
- Oral focal acantholytic dyskeratosis (warty dyskeratoma): Report of two casesOral Surgery, Oral Medicine, Oral Pathology, 1975
- Focal acantholytic dyskeratosisArchives of Dermatology, 1972
- Warty dyskeratoma (isolated dyskeratosis follicularis) of the oral mucosaOral Surgery, Oral Medicine, Oral Pathology, 1971
- Warty dyskeratoma. A note concerning its occurrence on the oral mucosaArchives of Dermatology, 1967