Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

This publication has 19 references indexed in Scilit:

• The Minimum Functional Unit of Human P-glycoprotein Appears to be a Monomer
  Published by Elsevier ,1996
• P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.
  Proceedings of the National Academy of Sciences, 1996
• GENETIC ANALYSIS OF THE MULTIDRUG TRANSPORTER
  Annual Review of Genetics, 1995
• Rapid Purification of Human P-glycoprotein Mutants Expressed Transiently in HEK 293 Cells by Nickel-Chelate Chromatography and Characterization of their Drug-stimulated ATPase Activities
  Published by Elsevier ,1995
• Covalent Modification of Human P-glycoprotein Mutants Containing a Single Cysteine in Either Nucleotide-binding Fold Abolishes Drug-stimulated ATPase Activity
  Published by Elsevier ,1995
• P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site
  Published by Elsevier ,1995
• Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
  Published by Elsevier ,1994
• A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.
  Proceedings of the National Academy of Sciences, 1991
• Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.
  Molecular and Cellular Biology, 1989
• Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
  Cell, 1986