THE EFFECT OF NORETHISTERONE ON ANTERIOR PITUITARY FUNCTION, STEROID METABOLISM AND BASAL TEMPERATURE IN MALES

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Abstract
The effects of 200 or 300 mg norethisterone oenanthate i. m. or of 20 mg norethisterone daily by mouth for 16 days on anterior pituitary function, steroid metabolism and on basal body temperature were investigated in five males without any demonstrable endocrine disturbance. During a 7 day pre-treatment and a 14 day treatment period, the behaviour of basal body temperature, of oestrogens, Porter-Silber chromogen (PSC) and gonadotrophin excretion, was studied. In addition, an intravenous loading dose of corticotrophin was given once in the pretreatment and once in the treatment period. No definite effect on gonadotrophin and oestrogen excretion was established. Values of total PSC were practically identical, but the average value of free PSC in urine during the treatment period was significantly higher. An intravenous loading dose of corticotrophin also showed a significantly higher rise in plasma free PSC at this period. The findings are briefly discussed with reference to the literature.

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