Ornithine Decarboxylase Activity in the Artificially Stimulated Decidual Cell Reaction in the Mouse Uterus1

Abstract
Changes in ornithine decarboxylase (ODC) activity in the mouse uterus following stimulation of the decidual cell reaction (DCR) were examined. ODC activity in the stimulated horn increased 6-fold over sham-operated controls 6 hours after intraluminal injection of [sesame] oil. Six hours after trauma stimulation, the activity of ODC in the stimulated horn increased 4-fold over contralateral control horns. Indomethacin pretreatment, previously shown to block the oil-stimulated DCR, blocks the increase in ODC activity in the oil-stimulated horn. Increased ODC activity is apparently an early event following stimulation of the DCR and may be causally related to the cellular proliferation which occurs as part of the process.

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