SIDE REACTIONS IN PEPTIDE-SYNTHESIS .10. PREVENTION OF O-ACYLATION DURING COUPLING WITH ACTIVE ESTERS
- 1 January 1979
- journal article
- research article
- Vol. 13 (1) , 22-27
Abstract
Acylation of the hydroxyl groups in the side chains of serine, threonine or tyrosine occurs in coupling with active esters. This side reaction, which is quite pronounced in histidine-containing peptides, can be prevented with additives. Of a series of compounds tested, 2,4-dinitrophenol and pentachlorophenol were the most effective.This publication has 4 references indexed in Scilit:
- SIDE REACTIONS IN PEPTIDE-SYNTHESIS .9. SUPPRESSION OF THE FORMATION OF AMINOSUCCINYL PEPTIDES WITH ADDITIVES1978
- Side reactions in peptide synthesis. 4. Extensive O-acylation by active esters in histidine containing peptidesThe Journal of Organic Chemistry, 1977
- Vasoactive intestinal peptide (VIP) from chickenBioorganic Chemistry, 1976
- Synthese einer teilgeschützten A-Kette des SchafinsulinsZeitschrift für Naturforschung B, 1965