POTENT TUMOR-INITIATING ACTIVITY OF THE 3,4-DIHYDRODIOL OF 7,12-DIMETHYLBENZ(A)ANTHRACENE IN MOUSE SKIN
- 1 January 1979
- journal article
- research article
- Vol. 39 (6) , 1934-1936
Abstract
The abilities of the racemic trans-3,4-,5,6-, and 8,9-dihydrodiols of 7,12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a 2-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was much more active as a tumor initiator than the parent hydrocarbon. The 7,12-dimethylbenz(a)anthracene trans-5,6- and 8,9-dihydrodiols were essentially inactive as skin tumor initiators. The 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene is a proximal carcinogen and the bay region diol-epoxide may be the ultimate carcinogenic form of DMBA.This publication has 27 references indexed in Scilit:
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