Thyrocytes from Autoimmune Thyroid Disorders Produce the Chemokines IP-10 And Mig and Attract CXCR3+ Lymphocytes

Publisher Website
Google Scholar
Abstract
To better understand the selective migration of lymphocytes in autoimmune thyroid disorders (AITDs), we analyzed thy- roid samples and demonstrated an enhanced expression of the chemokines interferon (IFN)-inducible protein (Ip)-10 and regulated on activation normal T lymphocyte expressed and secreted (RANTES) in thyroids from AITD patients. Ip-10 and monokine induced by IFN- (Mig) were expressed in vivo in thyroid follicular cells (TFCs) from AITD thyroids. Inter- estingly, Ip-10 mRNA, although not basally detected in cul- tured TFCs, was strongly induced by IFN- and synergisti- cally increased by TNF- addition. Furthermore, high levels of Ip-10 protein were detected in the supernatants of IFN--stim- ulated TFCs. Likewise, Mig protein was strongly induced in

This publication has 0 references indexed in Scilit: