Role of Prostanoid DP Receptor Variants in Susceptibility to Asthma
Open Access
- 21 October 2004
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 351 (17) , 1752-1763
- https://doi.org/10.1056/nejmoa031785
Abstract
Previous genetic studies have associated the region of the human genome (14q22.1) containing the gene for the prostanoid DP receptor (PTGDR) with asthma. A study of a mouse model suggests that the receptor is required for the expression of the asthma phenotype. Our associations of asthma with functional genetic variants of PTGDR link these observations.Keywords
This publication has 30 references indexed in Scilit:
- A Major Susceptibility Gene for Asthma Maps to Chromosome 14q24American Journal of Human Genetics, 2002
- Chromosome 14 linkage analysis and mutation study of 2 serpin genes in allergic asthmatic familiesJournal of Allergy and Clinical Immunology, 2001
- The health economics of asthma and rhinitis. I. Assessing the economic impactJournal of Allergy and Clinical Immunology, 2001
- Genomic Approaches to Understanding AsthmaGenome Research, 2000
- Prostaglandin D 2 as a Mediator of Allergic AsthmaScience, 2000
- Suggestive Evidence for Genetic Linkage Between IgE Phenotypes and Chromosome 14q MarkersAmerican Journal of Respiratory and Critical Care Medicine, 1999
- A genome-wide search for asthma susceptibility loci in ethnically diverse populationsNature Genetics, 1997
- A genome-wide search for quantitative trait loci underlying asthmaNature, 1996
- Molecular Cloning and Characterization of the Human Prostanoid DP ReceptorJournal of Biological Chemistry, 1995
- International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methodsEuropean Respiratory Journal, 1995