THE RELATIONSHIP BETWEEN THE RESPONSE TO GROWTH HORMONE THERAPY AND PRE-TREATMENT GROWTH HORMONE SECRETORY STATUS

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Abstract
In 35 children (22 M, 13 F) aged between 5.3 years and 10.3 years who received Somatrem therapy for 1 year there was a curvi‐linear relationship between pre‐treatment GH secretory status (x) and response (y) (change in height velocity standard deviation score (SDS)) to therapy described by the equation y= A + B (e−Cx). A, B and C are constants. Dose of GH administered was found to be an important additional factor in determining respone to therapy. This was confirmed by stepwise multiple regression which resulted in a correlation coefficient of 0.74. These data suggest that in the assessment of response to GH therapy, pretreatment height velocity and/or GH secretory status as well as dose and frequency of GH administration need to be taken into account.