Hyperthyroidism and Mongolism

Abstract
Nine cases of hyperthyroidism in mongoloid children have been reported since 1946.1-7Since the relationship between these two disorders may be significant, we are reporting three more cases. Two of these cases differ from the others in that the patients also had diabetes mellitus. Though Gilchrist3did not elaborate further in his published history, his patient had a diabetic glucose tolerance curve. Report of Cases Case1.—A Negro female was born March 17, 1948 (Figure). The diagnosis of mongolism was made because of hypertelorism, epicanthal folds, simian line, and short, curved fifth fingers. At age five, she was put into a slow learners class in school. When 8 she was given thyroid extract, 0.75 gr a day, to "pep her up." She took it for about 1½ years. At age 9½, she became nervous, irritable, and developed tachycardia and fine tremor of the fingers. There was recent weight

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