INHIBITORY EFFECT OF PROSTAGLANDIN-F2-ALPHA ON THE GROWTH OF A HORMONE-DEPENDENT RAT MAMMARY-TUMOR

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (3) , 998-1000
Abstract
Growth of the rat hormone-dependent mammary adenocarcinoma MTW-9 was inhibited by prostaglandin [PG] F2.alpha.. This inhibition of tumor growth was associated with a marked reduction in serum progesterone concentrations. The inhibitory effect of PGF2.alpha. on tumor growth was abolished by concomitant injections of progesterone. The growth rates of coimplanted prolactin-secreting pituitary tumor MtTW-5 and plasma concentrations of prolactin and estradiol were not affected significantly by PGF2.alpha.. The effect of PGF2.alpha. on growth of rat mammary adenocarcinoma is probably mediated by progesterone.

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