EFFECT OF CO-ADMINISTRATION OF THYMINE OR THYMIDINE ON THE ANTI-TUMOR ACTIVITY OF 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL AND 5-FLUOROURACIL

  • 1 January 1980
    • journal article
    • research article
    • Vol. 71  (1) , 100-106
Abstract
The antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) on rat Yoshida sarcoma cells and mouse solid sarcoma 180 cells was enhanced by oral coadministration of uracil, thymine or thymidine to rats and mice. The activity was enhanced equally by thymine and uracil, but thymine caused loss in body weight. The antitumor activity of 5-fluorouracil (5-FU) was enhanced by thymine or uracil, but both caused loss in body wt. Degradation of 5-FU in vitro was inhibited more by thymine than by uracil. Phosphorylation of 5-FU was not inhibited by uracil, thymine or thymidine, even at 100 times the concentration of 5-FU. Probably, the mechanism of enhancement of the antitumor activity of FT-207 by thymine or thymidine was similar to that by uracil; uracil had more effect than thymine or thymidine in enhancing antitumor effect of these drugs to FT-207 without toxicity.

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