Correction of developmental abnormalities resulting from localized ultra‐violet irradiation of an amphibian egg

Publisher Website
Google Scholar
Abstract
Ultra‐violet irradiation of the vegetal hemisphere of uncleaved R. pipiens eggs results in the development of characteristic defects in neural morphogenesis. These defects can be prevented from occurring if U.V. irradiated embryos are either (1) incubated at low temperature (cryoreversion), (2) microinjected with oocyte homogenate, or (3) surgically manipulated by replacing their dorsal lip with the lip of a normal (non U.V. irradiated ) embryo at the time of gastrulation.