Von Willebrand's Disease

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Abstract
THE bleeding disorder known as von Willebrand's disease or pseudohemophilia has been characterized by a tendency to bleeding from the mucous membranes, a prolonged bleeding time, reduced plasma level of factor VIII (antihemophilic factor) and an autosomal-dominant mode of inheritance.1 2 3 4 5 The role of platelets in the pathogenesis of this disease has remained controversial. Some investigators have found such platelet anomalies as deficiency of platelet factor 3 in the thromboplastin-generation test, abnormal morphology under the electron microscope6 7 8 9 and abnormal osmotic resistance.10 Others have been unable to confirm the presence of a defect of platelet factor 3 in this disorder.2 In view . . .