Conserved lipoprotein H.8 of pathogenic Neisseria consists entirely of pentapeptide repeats
- 1 January 1989
- journal article
- research article
- Published by Wiley in Molecular Microbiology
- Vol. 3 (1) , 43-48
- https://doi.org/10.1111/j.1365-2958.1989.tb00102.x
Abstract
The pathogenic Neisseria, N. gonorrhoeae and N. meningitidis, possess an outer membrane protein (OMP), designated H.8, with a conserved monoclonal antibody (MAb)‐binding epitope. We determined the DNA sequence of a gonococcal H.8 gene, and confirmed the relationship between the cloned gene and the H.8 OMP by constructing a gonococcal mutant lacking H.8. The predicted H.8 OMP is a lipoprotein 71 amino acids in length, composed of 13 repeats of a consensus sequence AAEAP with perfect 5‐residue periodicity. The AAEAP units form a repeating epitope that comprises the entire predicted sequence of the protein.This publication has 28 references indexed in Scilit:
- Recombination among Protein II genes of Neisseria gonorrhoeae generates new coding sequences and increases structural variability in the Protein II familyMolecular Microbiology, 1988
- Localization of a conserved epitope and an azurin‐like domain in the H.8 protein of pathogenic NeisseriaMolecular Microbiology, 1987
- Identification and gene structure of an azurin-like protein with a lipoprotein signal peptide in Neisseria gonorrhoeaeFEMS Microbiology Letters, 1987
- Isolation and preliminary biochemical characterization of the gonococcal H.8 antigen.The Journal of Experimental Medicine, 1986
- Cloning of the structural genes of three H8 antigens and of protein III of Neisseria gonorrhoeae.The Journal of Experimental Medicine, 1986
- Analyses of gonococcal H8 antigen. Surface location, inter- and intrastrain electrophoretic heterogeneity, and unusual two-dimensional electrophoretic characteristics.The Journal of Experimental Medicine, 1985
- Opacity determinants of Neisseria gonorrhoeae: Gene expression and chromosomal linkage to the gonococcal pilus geneCell, 1984
- TECHNOLOGICAL EXAMINATION OF LOW‐FIRED TERRACOTTA STATUES FROM AYIA IRINI, KEAArchaeometry, 1982
- Tropomyosin-like seven residue periodicity in three immunologically distinct streptococal M proteins and its implications for the antiphagocytic property of the molecule.The Journal of Experimental Medicine, 1980
- The double helix coiled coil structure of murein lipoprotein from Escherichia coliJournal of Molecular Biology, 1978