Hemoglobinuria in Rats: A sensitive Test of Renal Filtering and Absorption of Peg-Hemoglobin, a Red Blood Cell Substitute
- 1 January 1994
- journal article
- research article
- Published by Taylor & Francis in Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
- Vol. 22 (3) , 535-541
- https://doi.org/10.3109/10731199409117881
Abstract
Hemoglobinuria, defined as hemoglobin or hemoglobin subunits in the urine, is an easily monitored, sensitive indicator of renal handling of hemoglobin-based blood substitutes. Hemoglobin tetramer dissociation increases filtration by the kidneys. When the rate of filtration exceeds reabsorption, hemoglobinuria occurs. This study investigates the renal filtration and absorption of polyethylene glycolmodified bovine hemoglobin by monitoring for hemoglobinuria in several model systems.Keywords
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