Mechanism of Hematopoietic Recovery in the X-Irradiated Mouse with Spleen or One Leg Shielded

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Abstract
Mice with spleen or one leg shielded were given 600 R of X-irradiation, and the mechanism of hematopoietic recovery was studied on the basis of 59 Fe uptake in the organ, histological observation, and stem-cell kinetics. Whole-body-irradiated mice served as controls. The following results were obtained: (1) After irradiation, hematopoietic recovery in the exposed organ (spleen or femur) of the experimental animals took place earlier than in the controls. (2) In the experimental animals, hematopoiesis in the exposed femur increased significantly within 10 days after irradiation, whereas hematopoietic activity in the shielded one decreased during the same period. (3) The inverse course between the exposed organ and the shielded one was also demonstrated on the level of the stem cell-that is, erythropoietin-responsive cells and colony-forming cells. These facts suggest that stem cells in the shielded organ migrate into the exposed one, where they proliferate and differentiate so intensively as to make a contribution to early hemtopoietic recovery.