Discordant sex in one of three monozygotic triplets.
Open Access
- 2 February 1985
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 22 (1) , 6-11
- https://doi.org/10.1136/jmg.22.1.6
Abstract
A case is reported of monozygotic triplets, discordant for phenotypic sex, in which the female presented at birth with the features of Turner's syndrome. Chromosomal analyses showed homogeneous 46,XY karyotypes in the lymphocytes of the three sibs, while a 45,X non-mosaic chromosome constitution was detected in skin fibroblasts of the female triplet. It is suggested that mitotic non-disjunction or anaphase lag occurring early during embryonic development accounted for the occurrence of monosomy X in one cell line of the affected triplet. Previous observations of monozygotic twin pairs discordant for chromosome constitutions are reviewed.This publication has 21 references indexed in Scilit:
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