Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis
- 27 February 2005
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 8 (4) , 413-414
- https://doi.org/10.1038/nn1414
Abstract
Understanding the neurobiology of motivation might help in reducing compulsive behaviors such as drug addiction or eating disorders. This study shows that excitatory synaptic transmission was enhanced in the bed nucleus of the stria terminalis of rats that performed an operant task to obtain cocaine or palatable food. There was no effect when cocaine or food was delivered passively, suggesting that synaptic plasticity in this area is involved in reward-seeking behaviors.Keywords
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