Ethanol Effects on Hepatic Oxidations and Gluconeogenesis

Abstract
Effect of ethanol administration of hepatic metabolism was studied. After the ethanol administration (5 g/kg ip) blood alcohol concentration reached a maximum level in 60 min and there was no detectable alcohol after 12 hr. Glycogen concentration decreased after ethanol administration. Total liver lipid exhibited a maximal increase in 12 hr after ethanol administration. Oxidation of 14C alanine and 14C glucose was impaired at 10 min, 1, and 12 hr after ethanol administration. However, the incorporation of 14C alanine into glucose was increased in 1–12 hr.

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