Liver toxicity caused by nevirapine
- 1 January 2002
- journal article
- research article
- Published by Wolters Kluwer Health in AIDS
- Vol. 16 (2) , 290-291
- https://doi.org/10.1097/00002030-200201250-00020
Abstract
Nevirapine plasma levels were measured in 70 HIV-infected patients, 33 of whom developed transaminase elevations. Higher nevirapine levels and hepatitis C virus infection were found to be independent predictors of liver toxicity. Moreover, in individuals with chronic hepatitis C, nevirapine concentrations greater than 6 microg/ml were associated with a 92% risk of liver toxicity. Therefore, monitoring nevirapine levels, especially in individuals with chronic hepatitis C, may be warranted.Keywords
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