Zur Wirkung vonβ-Phenyläthylaminen auf in vitro gezüchtete Zellen

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Abstract
To be active as a mitosis-inhibitor of the colchicine type the tyramine nucleus appears necessary. A number of [beta]-phenylethyl-amines were tested on the cell division of embryonic chick heart fibroblasts (cultured in vitro) for inhibitory activity. Some showed activity. Adrenaline was found active, but only after oxidation. Vit. C and glutathione antagonized the action of adrenaline by preventing the oxidation of adrenaline to an unknown active compound. Adrenochrome was not assayed for activity. Corbasil (a methyl adrenaline) was not active. Adrenaline showed some inhibition of division in a culture of Ehrlich mouse carcinoma. The suggestion is advanced that the organism has its own mitosis inhibitors (adrenaline may be one). Cancer cells show a high conc, of reducing compounds (-SH, ascorbic acid) which antagonize adrenaline inhibition of mitosis.

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