Testosterone in the Management of Cirrhosis of the Liver- A Controlled Study

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Abstract
Results of a controlled study covering 21 cases of decompensated hepatic cirrhosis are reported. Nine controls received conventional therapy with diuretics [furosemide] and vitamin supplement. Testosterone 100 mg i.m. on alternate days for 4 wk was administered to 12 others in addition to conventional therapy. Patients in the testosterone group responded with reduction in ascites and pedal edema together with a subjective feeling of improvement. Serum albumin rose at the end of the 4 wk, while globulin fell in those that received the hormone. The difference in respect of both serum albumin and globulin in the testosterone group became statistically significant at the end of 4 wk.