Influences of Cisplatin Combination Chemotherapy on Oxygen Radical Generation by Blood in Elderly and Adult Patients with Lung Cancer

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Abstract
Oxygen radical generation by blood cells before and after chemotherapy was investigated in 16 elderly (72.8 +/- 1.0 years) and 14 adult (45.0 +/- 2.4 years) patients with lung cancer, using a lucigenin-dependent chemiluminescence method. The oxygen radical generation by 100 microliters of blood before chemotherapy in the elderly and the adults was 3,784 +/- 123 and 3,969 +/- 125 chemiluminescence (CL), respectively. The value decreased gradually and reached a nadir at 2 weeks after therapy (elderly: 1,090 +/- 37; adult: 1,114 +/- 38 CL). Peripheral leukocyte counts also reached a nadir then: 1,308 +/- 140 and 1,288 +/- 44/mm3, respectively. However, the oxygen-radical-generating activity per leukocyte was not different before and after the therapy (elderly: 0.94 +/- 0.14 CL before to 0.83 +/- 0.09 CL after; adult: 0.97 +/- 0.13 CL before to 0.87 +/- 0.10 CL after). These results indicate that a decrease in oxygen radical generation by blood following chemotherapy is mainly due to a decrease in the number of polymorphonuclear neutrophils both in elderly and adult patients.

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