Evidence for in situ amplification of a germ line homogeneously staining region in the mouse
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 47 (1-2) , 84-85
- https://doi.org/10.1159/000132512
Abstract
A cloned DNA sequence that is specific for a germ line homogeneously staining region (HSR) on chromosome 1 of the mouse was found to be homologous to a single copy sequence in non-HSR mice. By in situ hybridization, the sequence in non-HSR mice was localized to approximately the same site as the insertion site of the HSR on chromosome 1 of HSR mice, indicating in situ amplification of the HSR.This publication has 5 references indexed in Scilit:
- Microclones from a mouse germ line HSR detect amplification and complex rearrangements of DNA sequences.The EMBO Journal, 1987
- Moderate-level gene amplification in methotrexate-resistant Chinese hamster ovary cells is accompanied by chromosomal translocations at or near the site of the amplified DHFR gene.Molecular and Cellular Biology, 1984
- An extra segment in chromosome 1 of wild Mus musculus: a C-band positive homogeneously staining regionCytogenetic and Genome Research, 1984
- Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridizationChromosoma, 1981
- Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.Proceedings of the National Academy of Sciences, 1978