Deposition of β1h globulin in kidneys of patients with immune renal disease

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Abstract
Renal biopsies from patients with a variety of immune type renal diseases were examined by immunofluorescence for the presence of C3 [complement component 3] and its control protein, .beta.1H globulin. Deposits of .beta.1H were found in every instance (21 of 21 biopsies) in which C3 deposits were observed, irrespective of the underlying disease resulting in the C3 deposits including lupus nephritis, acute poststreptococcal glomerulonephritis, idiopathic membranous glomerulonephritis and Goodpasture''s syndrome. In no instance was .beta.1H found independently of C3. As previously shown in in vitro systems, .beta.1H also binds to C3, presumably C3b [b fragment of C3], during activation of the complement system in immunologically induced renal disease.