Long‐lasting neurological sequelae after lithium intoxication

Publisher Website
Google Scholar
Abstract
A combined literature study and correspondence follow up provided information about the development and further course of long lasting neurological sequelae after Li intoxication in 40 patients (28 women and 12 men). The circumstances surrounding the acute intoxications were examined. Possible precipitating circumstances included somatic illness with fever (11 cases), concurrent treatment with low-salt diet and diuretics (1), major surgery (1), low food intake (2), recent start with large Li doses (3), acute overdose with suicidal intent (4), overdose due to pharmacy, laboratory or patient mistakes (6) and concurrent treatment with large doses of haloperidol in the presence of fever (4). In 5 cases no likely precipitant could be found, and in 3 cases there was no information about the circumstances of the acute intoxication. The neurological sequelae developed following abatement of the acute intoxication and typically showed cerebellar affection with ataxia and scanning speech. Other brain regions could be affected, and peripheral neuropathy occurred. Improvement was in some cases seen during the first 6-12 mo., supported psychologically and perhaps also functionally by physiotherapy, speech therapy and general rehabilitation. Measures and guidelines to prevent the development of intoxications and permanent neurological sequelae are discussed. Warnings and precautions are provided.

This publication has 25 references indexed in Scilit: