Properties of Structurally Restricted Antibody to Type VIII Pneumococcal Polysaccharide
Open Access
- 1 May 1970
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 104 (5) , 1149-1154
- https://doi.org/10.4049/jimmunol.104.5.1149
Abstract
Following three courses of immunization with type VIII pneumococci, the serum of one rabbit showed an unusually marked increase in electrophoretically-restricted γ globulin components consisting of anti-polysaccharide antibodies. Examination of the intact purified antibodies by isoelectric focusing and of the corresponding light chains by disc gel electrophoresis in urea disclosed a less complex banding pattern than was observed with antibody isolated from serum of a rabbit showing a diffuse increase in globulin components after immunization. The serum concentration of the electrophoretically-restricted γ globulin components increased and subsequently decreased after each course of immunization. Histologic examination following the third course showed evidence of an intense immune response; plasma cell tumors were not seen.Keywords
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