Dye Dilution Measurement of the Renal Blood Flow: Observations of the Down Slope of the Dye Dilution Curve

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Abstract
The dye dilution curves from twelve human kidneys were compared with systemic curves from the same individuals recorded at the same time. The recirculation distance was the same for both types of recording. The renal curves were constantly influenced by recirculating dye. The initial deviation from the linear semilogarithmic extrapolation of the down slope of the renal curves occurred before the minimal re-circulation time and could be caused by inadequate mixing of dye in the renal artery, leakage of dye into the extravascular space or by the medullary circulation.