Changes in Alkaline Phosphatase Activity of Rat Oral Epithelium During the Estrous Cycle and in Response to Administered Estrogen

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Abstract
Appln. of the Gomori technic for histochemical localization of alkaline phosphatase demonstrates an increased activity of this enzyme in the buccal epithelium of albino female rats in response to elevated blood level of estrogenic hormone. Enzymatic activity is low in diestrus and in the ovariectomized animal and reaches a maximum in estrus and in spayed animals receiving estradiol benzoate by subcut. injn. Gingival epithelium exhibits only negligible activity of alkaline phosphatase regardless of estrogen level. The distr. of demonstrable phosphatase in the normally cornified buccal epithelium of the rat suggests a relationship to the process of keratin formation.