OBSERVATIONS ON THE CHEMICAL INHIBITION OF STREPTOMYCES GRISEUS BACTERIOPHAGE MULTIPLICATION

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Abstract
Multiplication of the bacteriophages infecting S. griseus may be limited by the addition of substances capable of sequestering Ca in the media before infection of the host cells occurs. Among the sequestering agents found effective in inhibiting bacteriophage multiplication in submerged culture fermentations without impairing streptomycin production are citrate, oxalate, and phytate. The effectiveness of the inhibition of bacteriophage multiplication may be reversed by the addition of metallic ions forming complexes with these sequestering agents.