Efficacy of SCH56592 in a Rabbit Model of Invasive Aspergillosis
- 1 March 2000
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 44 (3) , 780-782
- https://doi.org/10.1128/aac.44.3.780-782.2000
Abstract
SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.Keywords
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