The metabolism of the 10,11-dihydrodiol of benz[a]-anthracene to a vicinal diol-epoxide that is not involved in metabolic activation
- 1 November 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 1 (11) , 937-943
- https://doi.org/10.1093/carcin/1.11.937
Abstract
Benz[a]anthracene-10,11-diol, a major metabolite of benz[a]anthracene, is metabolized by a rat-liver microsomal system to form anti -BA-10,11-diol 8, 9-oxide ( t -10, r -11-dihydroxy- t -8,9-oxy-8,9, 10,11-tetrahydrobenz[a]anthracene) and, to a lesser extent, syn -BA-10,11-diol 8,9-oxide ( t -10 r -11-dihydroxy- c -8,9-oxy-8,9,10,11-tetrahydrobenz[a]anthracene). However, when benz[a]anthracene is incubated with DNA in a rat-liver microsomal system, anti -BA-10,11-diol 8,9-oxide does not contribute to the covalent binding of this hydrocarbon to DNAKeywords
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