The Role of Upper Airways in Antigen-Induced Bronchoconstriction

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Abstract
The bronchoconstrictor effect of antigen [Ag] was tested in 15 dogs. The upper and the lower airways were sequently exposed through a specially confected endotracheal tube. The Ag was generally administered through a mouth mask. Bronchoconstriction was induced after each kind of exposure. The results suggest reflex bronchoconstriction. The sensory receptors localized in the upper part of the airways are responsible for about 50% of Ag-induced bronchoconstriction. The decrease of PO2a [arterial oxygen pressure] was less marked following Ascaris suum extract aerosol administration to the upper part of the airways. Control measurements demonstrated the reproducibility of Ag-induced bronchoconstriction.
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